| Cardinals | | | | | | Rattlers |
November 6, 2021  11:45 pm | November 6, 2021  12:00 am BYE |
| Cardinals | Rattlers |
November 13, 2021 12:00 am BYE | November 13, 2021 4:00 pm  Hernando High School |
| BYE |
| | Cardinals | Lions | |
| | November 20, 2021 12:00 am BYE | November 20, 2021 4:00 pm  Paradise Sports Complex | Gators |
November 6, 2021 12:00 am | November 6, 2021  28-38 |
| BYE | Cardinals | Lions |
| | November 27, 2021 10:00 am | |
| | Lions |
| | |
| | Braves |
November 6, 2021 12:00 am | November 6, 2021  31-0  |
| | Firehawks | Braves |
November 13, 2021 12:00 am | | November 13, 2021 8-38 New Smyrna Beach Stadium |
| | Canes |
| | BYE | Firehawks | |
| | | | Firehawks |
November 6, 2021 12:00 am | November 6, 2021 25-6  |
| | Firehawks |
| | |
| | Bucs |
